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Mastocytosis - Symptoms & Treatment


Mastocytosis is a faction of rare disorders of both children and adults caused by the occurrence of too many mast cells. You can find mast cells in skin, lymph nodes, interior organs (for instance the liver and spleen) and the linings of the lung, stomach, and intestine. Mast cells play a vital role in helping your immune system defend these tissues from disease. The most common appearance of mastocytosis is when mast cells accumulate on the skin, causing reddish brown spots or bumps. In rare cases, mastocytosis can involve other parts of the body, for instance the stomach, the intestines and the bone marrow. Even when the disease is measured as a possibility by the physician, the diagnosis can be intricate due to special technical requirements needed for biopsy and because of the problems with biochemical testing.

Mastocytosis can begin in people of at all age. It is generally mild in children, and they often outgrow it. There are three major types of mastocytosis. In a rare form, mast cells amass as a single mass in the skin (mastocytoma). Usually, a mastocytoma increase before age 6 months. Seldom, urticaria pigmentosa progresses to systemic mastocytosis during adulthood. In systemic mastocytosis, mast cells amass in the skin, stomach, intestines, liver, spleen, lymph nodes, and bones. Patients among mastocytosis frequently have a long history of chronic and acute signs that were recognized as mastocytosis. Skin lesions may or may not attend systemic mastocytosis. In children, a mastocytoma generally depart spontaneously.

Causes of Mastocytosis

Some causes & risk factors of Mastocytosis are as follows:

  • Cold or heat.
  • Emotional stress and pest bites.
  • Smoking.
  • Certain medicines.

Symptoms of Mastocytosis

Some sign and symptoms related to Mastocytosis are as follows:

  • Abdominal soreness.
  • Bone or muscle tenderness.
  • Diarrhea.
  • Anaphylaxis (shock from allergic or immune reason).
  • Nausea and vomiting.
  • Ulcers.

Treatment of Mastocytosis

Treatment can stop your mast cells from liberate histamine. It can also remain the histamine from causing problems. Proton pump inhibitors help decrease production of gastric acid, which is often amplified in patients with mastocytosis. Excess gastric acid can damage the stomach, esophagus, and small intestine. Corticosteroids can be used topically, inhaled, or systemically to lessen tenderness associated with mastocytosis. Antidepressants are a vital and often overlooked tool in the treatment of mastocytosis. Some antidepressants for instance doxepin are themselves potent antihistamines and can help reduce physical as well as cognitive symptoms. Ultraviolet light and corticosteroid ointment relate to the skin may be used to care for the skin symptoms of mastocytosis.

 

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